Synthesis and Antimicrobial Evaluation of Some New Thiazole, Thiazolidinone and Thiazoline Derivatives Starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde.
From: Department of Chemistry, Faculty of Science, Mansoura University, El-gomhuria street, El-Dakhlia, ET-35516 Mansoura, Egypt. Bondock@mans.edu.eg
European journal of medicinal chemistry
- Publish Date: Jul 2007
- ISSN: 0223-5234
- Volume: 42
- Issue: 7
- Pages: 948-54
- Medium: Print
- Language: English
- Citation (JAMA): Bondock Samir, Khalifa Wesam, Fadda Ahmed A, et al. Synthesis and Antimicrobial Evaluation of Some New Thiazole, Thiazolidinone and Thiazoline Derivatives Starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde.. Jul 2007;42:948-54
Abstract
The thiosemicarbazones (3 and 6) and N-arylidene cyanoacetohydrazide (12) were prepared and used as key intermediates for the synthesis of 4-thiazolidinones (4, 5, 7-9), thiazoles (10a,b and 11a-d) and thiazoline (13) derivatives. Treatment of 13 with a mixture of triethylorthoformate and acetic anhydride afforded thiazolo[5,4-d]pyrimidinone derivative (14). The newly synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.
Mesh Headings (Keywords): Aldehydes, Anti-Bacterial Agents, Antifungal Agents, Bacteria, Dose-Response Relationship, Drug, Fungi, Molecular Structure, Naphthalenes, Thiazoles
Check for Full Text / PubMed Unique Identifier (PMID): 17316908
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