The Cox-2 Inhibitor Parecoxib Produces Neuroprotective Effects in Mptp-lesioned Rats.
From: Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
European journal of pharmacology
- Publish Date: Apr 2007
- ISSN: 0014-2999
- Volume: 560
- Issue: 2-3
- Pages: 163-75
- Medium: Print
- Language: English
- Citation (JAMA): Reksidler Angela B, Lima Marcelo M S, Zanata Sílvio M, et al. The Cox-2 Inhibitor Parecoxib Produces Neuroprotective Effects in Mptp-lesioned Rats.. Eur. J. Pharmacol. Apr 2007;560:163-75
Abstract
The present study investigated the effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib (Bextratrade mark) in the prevention of motor and cognitive impairments observed in rats after an intranigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a model of the early phase of Parkinson’s disease. The treatment with parecoxib (10 mg/kg) administered prior to the surgery and daily (2 mg/kg) for the subsequent 21 days, prevented the MPTP-treated rats from presenting decreased locomotor and exploratory behavior, increased immobility, and impairment while performing the cued version of the Morris water maze. Furthermore, parecoxib treatment also significantly prevented the reduction of tyrosine hydroxylase protein expression in the substantia nigra (7, 14 and 21 days after surgery), and in the striatum (14 and 21 days after surgery) as immunodetected by western blotting. These results strongly suggest that parecoxib exerts a neuroprotective effect on motor, tyrosine hydroxylase expression, and cognitive functions as it prevents their impairments within the confines of this animal model of the early phase of Parkinson’s disease.
Mesh Headings (Keywords): Animals, Cyclooxygenase 2 Inhibitors, Exploratory Behavior, Hippocampus, Isoxazoles, MPTP Poisoning, Male, Maze Learning, Motor Activity, Neuroprotective Agents, Rats, Rats, Wistar, Tyrosine 3-Monooxygenase
Check for Full Text / PubMed Unique Identifier (PMID): 17320073
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.