Cdc25 Phosphatases: Structure, Specificity, and Mechanism.
From: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA. rudolph@biochem.duke.edu
Biochemistry
- Publish Date: Mar 2007
- ISSN: 0006-2960
- Volume: 46
- Issue: 12
- Pages: 3595-604
- Medium: Print
- Language: English
- Citation (JAMA): Rudolph Johannes, et al. Cdc25 Phosphatases: Structure, Specificity, and Mechanism.. Biochemistry Mar 2007;46:3595-604
Abstract
Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Because of their overexpression and correlation with poor prognosis in many diverse cancers, Cdc25 phosphatases are attractive targets for anticancer drug development. Over the past few years, much knowledge of the basic enzymology of the Cdc25 phosphatases that may aid in the development of specific inhibitors has been gained. We review herein the structure, specificity, and mechanism of the Cdc25 phosphatases with a special focus on the activity of Cdc25 phosphatases with native protein substrates.
Mesh Headings (Keywords): Animals, Binding Sites, Cell Cycle, Enzyme Inhibitors, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Proteins, Neoplasms, Protein Structure, Secondary, Protein Structure, Tertiary, Substrate Specificity, cdc25 Phosphatases
Check for Full Text / PubMed Unique Identifier (PMID): 17328562
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