Survival Following Relapse in Childhood Haematological Malignancies Diagnosed in 1974-2003 in Yorkshire, Uk.
From: Paediatric Epidemiology Group, Centre for Epidemiology and Biostatistics, 30-32 Hyde Terrace, University of Leeds, Leeds, UK. r.g.feltbower@leeds.ac.uk
British journal of cancer
- Publish Date: Apr 2007
- ISSN: 0007-0920
- Volume: 96
- Issue: 7
- Pages: 1147-52
- Medium: Print
- Language: English
- Citation (JAMA): Feltbower R G, Kinsey S E, Richards M, et al. Survival Following Relapse in Childhood Haematological Malignancies Diagnosed in 1974-2003 in Yorkshire, Uk.. Br. J. Cancer Apr 2007;96:1147-52
Abstract
We examined population-based information on relapsed childhood haematological cancers, investigating factors that might influence both overall survival and survival following relapse among the 1177 children (0-14 years) diagnosed with a haematological malignancy in Yorkshire from 1974 to 2003, of whom 342 (29%) relapsed at least once. Leukaemia patients from more deprived areas were significantly less likely to relapse (odds ratio=0.54, 95% confidence interval 0.32-0.93 for most deprived quintile vs least deprived quintile; P(trend)=0.06), especially those with acute myeloid leukaemia (P=0.04). Neither ethnic group nor distance to the main treatment centre was associated with risk of relapse. Overall, patients who relapsed at least once had 5-year survival rates of 46% (41-51%) compared with 79% (76-81%) of those who did not. Five-year survival rates from the time of first relapse increased from 20% in 1974-1983 to 45% in 1984-2003. Length of first remission was a strong predictor of survival for leukaemia with a 46% reduced risk of death for every additional year of event-free survival. Of children who experienced a relapse, 46% survived at least 5 years, whereas just under half of patients survived 5 years beyond disease recurrence. This provides a baseline for future comparisons and demonstrates that relapsed childhood cancer need not imply a poor outcome.
Mesh Headings (Keywords): Adolescent, Adult, Child, Child, Preschool, Disease-Free Survival, Great Britain, Hematologic Neoplasms, Humans, Infant, Infant, Newborn, Neoplasm Recurrence, Local, Risk Factors, Survival Rate, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17342086
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