Maternal Intake of Vitamin D During Pregnancy and Risk of Recurrent Wheeze in Children at 3 Y of Age.
From: Center for D-receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ccamargo@partners.org
The American journal of clinical nutrition
- Publish Date: Mar 2007
- ISSN: 0002-9165
- Volume: 85
- Issue: 3
- Pages: 788-95
- Medium: Print
- Language: English
- Citation (JAMA): Camargo Carlos A, Rifas-Shiman Sheryl L, Litonjua Augusto A, et al. Maternal Intake of Vitamin D During Pregnancy and Risk of Recurrent Wheeze in Children at 3 Y of Age.. Am. J. Clin. Nutr. Mar 2007;85:788-95
Abstract
BACKGROUND: Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown. OBJECTIVE: We hypothesized that a higher maternal intake of vitamin D during pregnancy is associated with a lower risk of recurrent wheeze in children at 3 y of age. DESIGN: The participants were 1194 mother-child pairs in Project Viva-a prospective prebirth cohort study in Massachusetts. We assessed the maternal intake of vitamin D during pregnancy from a validated food-frequency questionnaire. The primary outcome was recurrent wheeze, ie, a positive asthma predictive index (>or=2 wheezing attacks among children with a personal diagnosis of eczema or a parental history of asthma). RESULTS: The mean (+/-SD) total vitamin D intake during pregnancy was 548 +/- 167 IU/d. By age 3 y, 186 children (16%) had recurrent wheeze. Compared with mothers in the lowest quartile of daily intake (median: 356 IU), those in the highest quartile (724 IU) had a lower risk of having a child with recurrent wheeze [odds ratio (OR): 0.39; 95% CI: 0.25, 0.62; P for trend < 0.001]. A 100-IU increase in vitamin D intake was associated with lower risk (OR: 0.81; 95% CI: 0.74, 0.89), regardless of whether vitamin D was from the diet (OR: 0.81; 95% CI: 0.69, 0.96) or supplements (OR: 0.82; 95% CI: 0.73, 0.92). Adjustment for 12 potential confounders, including maternal intake of other dietary factors, did not change the results. CONCLUSION: In the northeastern United States, a higher maternal intake of vitamin D during pregnancy may decrease the risk of recurrent wheeze in early childhood.
Mesh Headings (Keywords): Body Mass Index, Child, Preschool, Diet, Female, Humans, Maternal Age, Odds Ratio, Pregnancy, Respiratory Sounds, Risk Factors, Vitamin D
Check for Full Text / PubMed Unique Identifier (PMID): 17344501
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.