The Igf-i Axis in Thyroid Carcinoma.
From: Section of Internal Medicine, Endocrinology and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Bari, Italy. a.ciampolillo@endo.uniba.it
Current pharmaceutical design
- Publish Date: 2007
- ISSN: 1873-4286
- Volume: 13
- Issue: 7
- Pages: 729-35
- Medium: Internet
- Language: English
- Citation (JAMA): Ciampolillo A, De Tullio C, Perlino E, et al. The Igf-i Axis in Thyroid Carcinoma.. Curr. Pharm. Des. 2007;13:729-35
Abstract
Insulin like-growth factor I (IGF-I) has been involved in the pathogenesis of a variety of human neoplasia due to the mitogenic and anti-apoptotic properties of its cognate receptor. In human thyroid carcinomas, we have previously documented an increased immunoreactivity of both IGF-I and the IGF-I receptor (IGF-I R) associated with up regulation of IGF-I mRNA . Immunoreactivity of IGF-I and cognate receptor positively correlated with tumor diameter and wide intrathyroidal extension but not with patient’s gender and age or with the stage of the tumors and the occurrence of limph node metastases. Most experimental studies indicate that the effects of IGF-I on target cells are regulated in a complex fashion and depend on the simultaneous occurrence of IGF-IR and the binding proteins.
Mesh Headings (Keywords): Animals, Apoptosis, Cell Cycle, Humans, Ligands, Protein Binding, Receptor, IGF Type 1, Signal Transduction, Somatomedins, Thyroid Gland, Thyroid Neoplasms
Check for Full Text / PubMed Unique Identifier (PMID): 17346187
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.