Cart Peptides Increase 5-hydroxytryptamine in the Dorsal Raphe and Nucleus Accumbens of Freely Behaving Rats.
From: Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA.
Neuroscience letters
- Publish Date: May 2007
- ISSN: 0304-3940
- Volume: 417
- Issue: 3
- Pages: 303-7
- Medium: Print
- Language: English
- Citation (JAMA): Ma Zhiyuan, Pearson Elliot, Tao Rui, et al. Cart Peptides Increase 5-hydroxytryptamine in the Dorsal Raphe and Nucleus Accumbens of Freely Behaving Rats.. Neurosci. Lett. May 2007;417:303-7
Abstract
Cocaine and amphetamine-regulated transcript peptides (CART) are implicated in the antidepressant effect. This may involve in 5-hydroxytryptamine (5-HT) in the CNS. The aim of the present studies was to investigate the effect of CART peptides on extracellular 5-HT in the dorsal raphe nucleus (DRN) and nucleus accumbens (NAcc) using a microdialysis approach in freely behaving rats. Reverse infusion of CART61-102 in the DRN produced a concentration (10-100 microM) -dependent increase in 5-HT in the DRN. Similarly, CART62-76 (10-100 microM) infused into the DRN and NAcc elevated 5-HT in the DRN and NAcc, respectively. Thus, CART increases extracellular 5-HT in both the DRN and NAcc. In addition, infusion of CART62-76 (100 microM) in the DRN produced a significant increase in 5-HT in the NAcc, implying an existence of CART receptors responsible for the depolarization-dependent release. In summary, the results of the present studies suggest that CART peptides may have an antidepressant effect through increases in extracellular 5-HT.
Mesh Headings (Keywords): Animals, Behavior, Animal, Brain Chemistry, Depressive Disorder, Dose-Response Relationship, Drug, Extracellular Fluid, Male, Microdialysis, Motor Activity, Nerve Tissue Proteins, Nucleus Accumbens, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Serotonin, Up-Regulation
Check for Full Text / PubMed Unique Identifier (PMID): 17346884
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