The Association of Serum Gamma Glutamyltransferase with Components of the Metabolic Syndrome in the Korean Adults.
From: Department of Internal Medicine, Pusan National University School of Medicine, 1-10 Ami-dong, Seo-ku, Busan 602-739, Republic of Korea.
Diabetes research and clinical practice
- Publish Date: Aug 2007
- ISSN: 0168-8227
- Volume: 77
- Issue: 2
- Pages: 306-13
- Medium: Print
- Language: English
- Citation (JAMA): Kang Yang Ho, Min Hong Ki, Son Seok Man, et al. The Association of Serum Gamma Glutamyltransferase with Components of the Metabolic Syndrome in the Korean Adults.. Diabetes Res. Clin. Pract. Aug 2007;77:306-13
Abstract
The metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease related to insulin resistance. Recently, serum gamma glutamyltransferase (GGT) has been proposed as a marker of oxidative stress and is associated with a marked increase in the risk of cardiovascular disease. So, we investigated the association between serum GGT and components of the metabolic syndrome in the Korean adults. A total 3246 adults (aged 20-70 years, 1622 men and 1624 women) who visited Center for Health Promotion in Pusan National University Hospital for a medical checkup were included. We measured serum GGT and lipid profiles, fasting glucose, fasting insulin and blood pressure. As the quartile of serum GGT increased, the number of components of MS and prevalence of MS were increased. Serum GGT was also increased according as the number of components of MS was increased. A significant correlation (r=0.200, p<0.001 in men and r=0.133, p<0.001 in women) was noted between the numbers of the components of the MS and serum GGT. In addition, serum GGT was correlated significantly (r=0.266, p<0.001 in men and r=0.264, p<0.001 in women) with homeostasis model assessment of insulin resistance (HOMA-IR). In linear regression model, serum GGT was mainly influenced by the concentration of triglycerides and fasting glucose. In conclusion, serum GGT is closely related with insulin resistance and the increased number of components of MS. Among components of MS, serum GGT may be more associated with dyslipidemia and abnormal glucose tolerance, suggesting that serum GGT has more relationship with hepatic insulin resistance regardless of non-alcoholic fatty liver disease.
Mesh Headings (Keywords): Adult, Aged, Alanine Transaminase, Aspartate Aminotransferases, Blood Glucose, Blood Pressure, Body Mass Index, Female, Humans, Insulin, Insulin Resistance, Korea, Male, Metabolic Syndrome X, Middle Aged, Prevalence, gamma-Glutamyltransferase
Check for Full Text / PubMed Unique Identifier (PMID): 17353063
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.