Cell Fate Polarization in Ascidian Mesenchyme/Muscle Precursors by Directed Fgf Signaling and Role for an Additional Ectodermal Fgf Antagonizing Signal in Notochord/Nerve Cord Precursors.
From: Faculty of Marine Bioscience and Technology, Kangnung National University, Gangneung Daehangno, Gangneung 210-702, Republic of Korea. gjkim@kangnung.ac.kr
Development (Cambridge, England)
- Publish Date: Apr 2007
- ISSN: 0950-1991
- Volume: 134
- Issue: 8
- Pages: 1509-18
- Medium: Print
- Language: English
- Citation (JAMA): Kim Gil Jung, Kumano Gaku, Nishida Hiroki, et al. Cell Fate Polarization in Ascidian Mesenchyme/Muscle Precursors by Directed Fgf Signaling and Role for an Additional Ectodermal Fgf Antagonizing Signal in Notochord/Nerve Cord Precursors.. Development Apr 2007;134:1509-18
Abstract
Asymmetric cell division plays a fundamental role in generating various types of embryonic cell. In ascidian embryos, asymmetric cell divisions occur in the vegetal hemisphere in a manner similar to those found in Caenorhabditis elegans. Early divisions in embryos of both species involve inductive events on a single mother cell that result in production of daughters with different cell fates. Here we show in the ascidian Halocynthia roretzi that polarity of muscle/mesenchyme mother precursors is determined solely by the direction from which the FGF9/16/20 signal is presented, a role similar to that of Wnt signaling in the EMS and T cell divisions in C. elegans. However, polarity of nerve cord/notochord mother precursors is determined by possible antagonistic action between the FGF signal and a signal from anterior ectoderm, providing a new mechanism underlying asymmetric cell division. The ectoderm signal suppresses MAPK activation and expression of Hr-FoxA, which encodes an intrinsic competence factor for notochord induction, in the nerve cord lineage.
Mesh Headings (Keywords): Animals, Body Patterning, Cell Differentiation, Cell Division, Cell Lineage, Ectoderm, Enzyme Activation, Fibroblast Growth Factors, MAP Kinase Signaling System, Mesenchymal Stem Cells, Myoblasts, Notochord, Signal Transduction, Stem Cells, Trans-Activators, Urochordata
Check for Full Text / PubMed Unique Identifier (PMID): 17360771
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