Eva Regulates Thymic Stromal Organisation and Early Thymocyte Development.
From: San Raffaele Scientific Institute, Milan, Italy.
Biochemical and biophysical research communications
- Publish Date: May 2007
- ISSN: 0006-291X
- Volume: 356
- Issue: 2
- Pages: 334-40
- Medium: Print
- Language: English
- Citation (JAMA): DeMonte Lucia, Porcellini Simona, Tafi Elisiana, et al. Eva Regulates Thymic Stromal Organisation and Early Thymocyte Development.. Biochem. Biophys. Res. Commun. May 2007;356:334-40
Abstract
Epithelial V-like antigen (EVA) is an immunoglobulin-like adhesion molecule identified in a screen for molecules developmentally regulated at the DN to DP progression in thymocyte development. We show that EVA is expressed during the early stages of thymus organogenesis in both fetal thymic epithelia and T cell precursors, and is progressively downregulated from day 16.5 of embryonic development. In the postnatal thymus, EVA expression is restricted to epithelial cells and is distributed throughout both cortical and medullary thymic regions. Transgenic overexpression of EVA in the thymus cortex resulted in a modified stromal environment, which elicited an increase in organ size and absolute cell number. Although peripheral T lymphocyte numbers are augmented throughout life, no imbalance either in the repertoire, or in the different T cell subsets was detected. Collectively, these data suggest a role for EVA in structural organisation of the thymus and early lymphocyte development.
Mesh Headings (Keywords): Animals, Cell Adhesion Molecules, Gene Expression Regulation, Developmental, Mice, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocyte Subsets, Thymus Gland
Check for Full Text / PubMed Unique Identifier (PMID): 17362876
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.