Integrin Signaling Regulates Spindle Orientation in Drosophila to Preserve the Follicular-epithelium Monolayer.
From: Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Cientificas, Universidad Pablo de Olavide, Carretera de Utrera km 1, 41013 Sevilla, Spain.
Current biology : CB
- Publish Date: Apr 2007
- ISSN: 0960-9822
- Volume: 17
- Issue: 8
- Pages: 683-8
- Medium: Print
- Language: English
- Citation (JAMA): Fernández-Miñán Ana, Martín-Bermudo María D, González-Reyes Acaimo, et al. Integrin Signaling Regulates Spindle Orientation in Drosophila to Preserve the Follicular-epithelium Monolayer.. Curr. Biol. Apr 2007;17:683-8
Abstract
Epithelia act as important physiological barriers and as structural components of tissues and organs. In the Drosophila ovary, follicle cells envelop the germline cysts to form a monolayer epithelium. During division, the orientation of the mitotic spindle in follicle cells is such that both daughter cells remain within the same plane, and the simple structure of the follicular epithelium is thus preserved. Here we show that integrins, heterodimeric transmembrane receptors that connect the extracellular matrix to the cell’s cytoskeleton [1, 2], are required for maintaining the ovarian monolayer epithelium in Drosophila. Mosaic egg chambers containing integrin mutant follicle cells develop stratified epithelia at both poles. This stratification is due neither to abnormal cell proliferation nor to defects in the apical-basal polarity of the mutant cells. Instead, integrin function is required for the correct orientation of the mitotic apparatus both in mutant cells and in their immediately adjacent wild-type neighbors. We further demonstrate that integrin-mediated signaling, rather than adhesion, is sufficient for maintaining the integrity of the follicular epithelium. The above data show that integrins are necessary for preserving the simple organization of a specialized epithelium and link integrin-mediated signaling to the correct orientation of the mitotic spindle in this epithelial cell type.
Mesh Headings (Keywords): Animals, Drosophila, Drosophila Proteins, Epithelium, Female, Integrins, Mitotic Spindle Apparatus, Ovarian Follicle, Ovary, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 17363255
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.