Promotion of Skin Epithelial Cell Migration and Wound Healing by a 2-benzazepine Derivative.
From: Department of Pharmacology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, and Department of Surgical Pathology, Yamaguchi University Hospital, 755-8505, Japan.
European journal of pharmacology
- Publish Date: Jun 2007
- ISSN: 0014-2999
- Volume: 563
- Issue: 1-3
- Pages: 83-7
- Medium: Print
- Language: English
- Citation (JAMA): Matsuura Kenji, Kuratani Tomohiro, Gondo Toshikazu, et al. Promotion of Skin Epithelial Cell Migration and Wound Healing by a 2-benzazepine Derivative.. Eur. J. Pharmacol. Jun 2007;563:83-7
Abstract
Re-epithelialization is an important event in the healing of skin wounds. We have now shown that a 2-benzazepine derivative, N-(2,2,2-trifluoroethyl)-8-methoxy-4-methyl-2-benzazepin-3-one (compound A), facilitated the migration of human keratinocyte HaCat cells in an in vitro model of wound healing and inhibited the attachment of these cells to a collagen matrix. Topical application of compound A also promoted the healing of skin wounds in mice. Our results suggest that compound A promotes the repair of skin wounds by facilitating epithelial cell migration and that this 2-benzazepine derivative is a potential new drug for the treatment of such wounds.
Mesh Headings (Keywords): Animals, Benzazepines, Cell Adhesion, Cell Line, Transformed, Cell Movement, Collagen Type I, Dose-Response Relationship, Drug, Humans, Keratinocytes, Mice, Mice, Inbred BALB C, Skin, Time Factors, Wound Healing
Check for Full Text / PubMed Unique Identifier (PMID): 17368615
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