Mechanism of Changes Induced in Plasma Glycerol by Scent Stimulation with Grapefruit and Lavender Essential Oils.
From: Institute for Protein Research, Osaka University, 3-2 Yamada-Oka, Suita, Osaka 565-0871, Japan. jshen@ymp-i.co.jp
Neuroscience letters
- Publish Date: Apr 2007
- ISSN: 0304-3940
- Volume: 416
- Issue: 3
- Pages: 241-6
- Medium: Print
- Language: English
- Citation (JAMA): Shen Jiao, Niijima Akira, Tanida Mamoru, et al. Mechanism of Changes Induced in Plasma Glycerol by Scent Stimulation with Grapefruit and Lavender Essential Oils.. Neurosci. Lett. Apr 2007;416:241-6
Abstract
In a previous study, we found that stimulation with scent of grapefruit oil (SGFO) elevated plasma glycerol levels in rats. However, stimulation with scent of lavender oil (SLVO) triggered a negative effect. To identify the mechanism of these changes during lipolysis, we examined the role of autonomic blockers and bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) in the modification of plasma glycerol in rats exposed to SGFO and SLVO. We found that intraperitoneal injection of propranolol hydrochloride and atropine sulfate eliminated the changes in plasma glycerol levels induced by SGFO and SLVO, respectively. Bilateral lesions of the SCN completely abolished the effects of SGFO and SLVO on lipolysis. In addition, we investigated tyrosine phosphorylation of the transmembrane glycoprotein BIT (a brain immunoglobulin-like molecule with tyrosine-based activation motifs, a member of the signal-regulator protein family), which was found to be involved in the activation of renal sympathetic nerves and increase in body temperature on cold exposure. SGFO was found to enhance the immunoreactivity of BIT to the 4G10 anti-phosphotyrosine antibody in the SCN, whereas SLVO decreased the immunoreactivity. The changes in BIT phosphorylation resulting from the exposure to SGFO and SLVO were eliminated by the corresponding histamine receptor antagonists, which eliminated the changes in plasma glycerol concentration. The results suggest that SGFO and SLVO affect the autonomic neurotransmission and lipolysis. The SCN and histamine neurons are involved in the lipolytic responses to SGFO and SLVO, and tyrosine phosphorylation of BIT is implicated in the relevant signaling pathways.
Mesh Headings (Keywords): Adrenergic beta-Antagonists, Animals, Atropine, Citrus paradisi, Drug Interactions, Glycerol, Histamine H1 Antagonists, Isothiocyanates, Male, Muscarinic Antagonists, Oils, Volatile, Olfactory Pathways, Physical Stimulation, Plant Oils, Plasma, Propranolol, Rats, Rats, Wistar, Smell, Suprachiasmatic Nucleus, Tyrosine
Check for Full Text / PubMed Unique Identifier (PMID): 17376592
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.