A Comparison of the Influence of a High-fat Diet Enriched in Monounsaturated Fatty Acids and Conventional Diet on Weight Loss and Metabolic Parameters in Obese Non-diabetic and Type 2 Diabetic Patients.
From: Centre for Research of Diabetes, Metabolism and Nutrition and 2nd Department of Medicine of the 3rd Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic. brunerova@seznam.cz
Diabetic medicine : a journal of the British Diabetic Association
- Publish Date: May 2007
- ISSN: 0742-3071
- Volume: 24
- Issue: 5
- Pages: 533-40
- Medium: Print
- Language: English
- Citation (JAMA): Brunerova L, Smejkalova V, Potockova J, et al. A Comparison of the Influence of a High-fat Diet Enriched in Monounsaturated Fatty Acids and Conventional Diet on Weight Loss and Metabolic Parameters in Obese Non-diabetic and Type 2 Diabetic Patients.. Diabet. Med. May 2007;24:533-40
Abstract
AIMS: The aim of our study was to compare the influence of a hypocaloric, high-fat diet enriched with MUFA (M) and conventional diet (C) on weight loss and metabolic parameters in obese non-diabetic and obese Type 2 diabetic subjects over a 3-month period. It was our hypothesis that the enriched diet would be more effective in decreasing blood glucose and glycated haemoglobin (HbA(1c)) than the control diet. METHODS: Twenty-seven Type 2 diabetic patients (54.5 +/- 3.5 years; DM), treated with diet or oral glucose-lowering agents, and 31 obese non-diabetic subjects (53.6 +/- 3.5 years; OB) were randomized to M or C. Individual calculations of energy requirements were based on the formula: [resting energy expenditure (REE) x 1.5] - 600 kcal. Subjects were assessed by a dietitian every 2 weeks and by a physician every month. Statistical analyses were carried out between the four groups — DM/M, DM/C, OB/M and OB/C — using pair Student’s test and anova. RESULTS: After 3 months, body weight, waist-hip ratio, total body fat, levels of C-peptide, triglycerides and homeostasis model assessment (HOMA) decreased in all four groups (P < 0.01). However, fasting blood glucose and HbA(1c) decreased (P < 0.01) and high-density lipoprotein cholesterol increased significantly only in the DM/M group (P < 0.05). In general, M was well tolerated. CONCLUSIONS: Individualized M and C diets were successful in improving metabolic and anthropometric parameters in both the obese non-diabetic and the Type 2 diabetic subjects. Although the superiority of the higher fat diet did not reach statistical significance, the decline in blood glucose and HbA(1c) in the Type 2 diabetic group on M was encouraging.
Mesh Headings (Keywords): Blood Glucose, Diabetes Mellitus, Type 2, Diabetic Diet, Dietary Fats, Fatty Acids, Monounsaturated, Humans, Middle Aged, Obesity, Weight Loss
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