The Actin-based Motor Protein Myosin Ii Regulates Mhc Class Ii Trafficking and Bcr-driven Antigen Presentation.
From: Institut National de la Santé et de la Recherche Medicale Unité 653, Unité Mixte de Recherche 144 Institut Curie, 75005 Paris, France.
The Journal of cell biology
- Publish Date: Mar 2007
- ISSN: 0021-9525
- Volume: 176
- Issue: 7
- Pages: 1007-19
- Medium: Print
- Language: English
- Citation (JAMA): Vascotto Fulvia, Lankar Danielle, Faure-André Gabrielle, et al. The Actin-based Motor Protein Myosin Ii Regulates Mhc Class Ii Trafficking and Bcr-driven Antigen Presentation.. J. Cell Biol. Mar 2007;176:1007-19
Abstract
Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.
Mesh Headings (Keywords): Actins, Animals, Antigen Presentation, B-Lymphocytes, CD4-Positive T-Lymphocytes, Cells, Cultured, Histocompatibility Antigens Class II, Lymphocyte Activation, Lysosomes, Macromolecular Substances, Mice, Mice, Transgenic, Myosin Type II, Protein Transport, Receptors, Antigen, B-Cell, Transport Vesicles
Check for Full Text / PubMed Unique Identifier (PMID): 17389233
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