Glucose Tolerance Status and Cognitive Impairment in Early Middle-aged Women.
From: Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. jlfuh@vghtpe.gov.tw
Diabetic medicine : a journal of the British Diabetic Association
- Publish Date: Jul 2007
- ISSN: 0742-3071
- Volume: 24
- Issue: 7
- Pages: 788-91
- Medium: Print
- Language: English
- Citation (JAMA): Fuh J-L, Wang S-J, Hwu C-M, et al. Glucose Tolerance Status and Cognitive Impairment in Early Middle-aged Women.. Diabet. Med. Jul 2007;24:788-91
Abstract
AIMS: To examine the effect of glucose tolerance status on cognitive performance in early middle-aged women. METHODS: We conducted a matched, case-control study from a population-based cohort in Kinmen, Taiwan. Women aged 40-54 years were recruited. Participants were classified into one of three groups: normal, impaired glucose tolerance (IGT) or diabetes mellitus. Cognitive measures used were the Rey Auditory-Verbal Learning Test, visual memory, verbal fluency, Trail Making Test, and digit spans. RESULTS: Seven hundred and twenty eligible women underwent both the cognitive and oral glucose tolerance tests. The 72 women (10%) who had diabetes mellitus were compared with 68 women with IGT and 144 with normal glucose tolerance. All groups were matched for age and education level. Mean scores on cognitive testing did not differ between the three groups, except for the forward digit spans test. After adjustment for menopausal status, psychological stress scores and other cardiovascular variables, glucose tolerance status was no longer a significant predictor for forward digit span scores. CONCLUSIONS: Glucose tolerance status was not associated with cognitive performance in middle-aged women.
Mesh Headings (Keywords): Adult, Blood Glucose, Case-Control Studies, Cognition Disorders, Diabetes Mellitus, Female, Glucose Intolerance, Glucose Tolerance Test, Humans, Middle Aged, Neuropsychological Tests, Taiwan, Wechsler Scales
Check for Full Text / PubMed Unique Identifier (PMID): 17403114
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