A Novel Monolayer Cell Line Derived from Human Umbilical Cord Blood Cells Shows High Sensitivity to Measles Virus.
From: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
The Journal of general virology
- Publish Date: May 2007
- ISSN: 0022-1317
- Volume: 88
- Issue: Pt 5
- Pages: 1565-7
- Medium: Print
- Language: English
- Citation (JAMA): Kobune Fumio, Ami Yasushi, Katayama Miki, et al. A Novel Monolayer Cell Line Derived from Human Umbilical Cord Blood Cells Shows High Sensitivity to Measles Virus.. J. Gen. Virol. May 2007;88:1565-7
Abstract
Measles virus (MeV) research is largely dependent on the B95a cell line, which is derived from marmoset B lymphocytes. As this cell line is persistently infected with Epstein-Barr virus (EBV), a novel cell line, COBL-a, was established from human umbilical cord blood. COBL-a cells have a significant advantage over B95a cells because they are of human origin, are free from EBV and have higher sensitivity to wild-type MeV. Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV.
Mesh Headings (Keywords): Animals, B-Lymphocytes, Blood Cells, Callithrix, Cell Line, Fetal Blood, Humans, Infant, Newborn, Measles virus
Check for Full Text / PubMed Unique Identifier (PMID): 17412987
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