Acute Nicotine Enhances C-fos Mrna Expression Differentially in Reward-related Substrates of Adolescent and Adult Rat Brain.
From: Department of Neuroscience, Centre for Addiction and Mental Health, Toronto, Ontario Canada M5S 2S1. megan_shram@camh.net
Neuroscience letters
- Publish Date: May 2007
- ISSN: 0304-3940
- Volume: 418
- Issue: 3
- Pages: 286-91
- Medium: Print
- Language: English
- Citation (JAMA): Shram Megan J, Funk Douglas, Li Zhaoxia, et al. Acute Nicotine Enhances C-fos Mrna Expression Differentially in Reward-related Substrates of Adolescent and Adult Rat Brain.. Neurosci. Lett. May 2007;418:286-91
Abstract
A number of studies have demonstrated that adolescent rodents are more sensitive to the rewarding effects of nicotine compared to adults. To help determine the potential brain circuitry involved, we investigated the effect of acute nicotine administration (0.4 or 0.8mg/kg, s.c.) on the expression of c-fos mRNA in the brains of adolescent (P35) and adult (P67-70) male Wistar rats using in situ hybridization. Nicotine administration increased c-fos mRNA expression in several brain regions, including the central amygdala, locus coeruleus, nucleus accumbens core, paraventricular nucleus of the hypothalamus and lateral septum of adolescent and adult rats. Nicotine increased c-fos mRNA expression more robustly in the bed nucleus of the stria terminalis, nucleus accumbens shell and ventral tegmental area in adolescent rats. The current results suggest that nicotine may have greater activational effects in brain regions associated with reward in adolescent rats and may help to explain the differences between adolescents and adults in behavioral responses to nicotine.
Mesh Headings (Keywords): Age Factors, Animals, Animals, Newborn, Behavior, Animal, Brain, Conditioning, Operant, Gene Expression Regulation, Genes, fos, Male, Nicotine, Nicotinic Agonists, RNA, Messenger, Rats, Rats, Wistar, Reward
Check for Full Text / PubMed Unique Identifier (PMID): 17420096
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.