Evidence for Imidazoline Receptors Involvement in the Agmatine Antidepressant-like Effect in the Forced Swimming Test.
From: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-900, SC, Brazil.
European journal of pharmacology
- Publish Date: Jun 2007
- ISSN: 0014-2999
- Volume: 565
- Issue: 1-3
- Pages: 125-31
- Medium: Print
- Language: English
- Citation (JAMA): Zeidan Mariana P, Zomkowski Andréa D E, Rosa Angelo O, et al. Evidence for Imidazoline Receptors Involvement in the Agmatine Antidepressant-like Effect in the Forced Swimming Test.. Eur. J. Pharmacol. Jun 2007;565:125-31
Abstract
This study investigated the involvement of the imidazoline receptors in the antidepressant-like effect of agmatine in the forced swimming test. The antidepressant-like effects of agmatine (10 mg/kg, i.p.) in the forced swimming test was blocked by pretreatment of mice with efaroxan (1 mg/kg, i.p., an imidazoline I1/alpha2-adrenoceptor antagonist), idazoxan (0.06 mg/kg, i.p., an imidazoline I2/alpha2-adrenoceptor antagonist) and antazoline (5 mg/kg, i.p., a ligand with high affinity for the I2 receptor). A subeffective dose of agmatine (0.001 mg/kg, i.p.) produced a synergistic antidepressant-like effect with clonidine (0.06 mg/kg, i.p, an imidazoline I1/alpha2-adrenoceptor agonist), moxonidine (0.5 mg/kg, i.p., an imidazoline I1/alpha2-adrenoceptor agonist), antazoline (1 mg/kg, i.p.) and MK-801 (0.001 mg/kg, i.p., a non-competitive NMDA receptor antagonist), but not with efaroxan (1 mg/kg, i.p.) and idazoxan (0.06 mg/kg, i.p.). Pretreatment of mice with yohimbine (1 mg/kg, i.p., an alpha2-adrenoceptor antagonist) blocked the synergistic antidepressant-like effect of agmatine (0.001 mg/kg, i.p.) with clonidine (0.06 mg/kg, i.p). A subeffective dose of MK-801 (0.001 mg/kg, i.p.) produced a synergistic antidepressant-like effect with antazoline (5 mg/kg, i.p.), but not with efaroxan (1 mg/kg, i.p.) or idazoxan (0.06 mg/kg, i.p.). In conclusion, this study suggests that the anti-immobility effect of agmatine in the forced swimming test is dependent on its interaction with imidazoline I1 and I2 receptors.
Mesh Headings (Keywords): Agmatine, Animals, Antazoline, Antidepressive Agents, Benzofurans, Clonidine, Female, Imidazoles, Imidazoline Receptors, Male, Mice, Receptors, Adrenergic, alpha-2, Receptors, Drug, Receptors, N-Methyl-D-Aspartate, Swimming
Check for Full Text / PubMed Unique Identifier (PMID): 17445795
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