Involvement of Gaba A Receptor-associated Chloride Channels in the Peripheral Antinociceptive Effect Induced by Gaba A Receptor Agonist Muscimol.
From: Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antônio Carlos 6627, 31270-100 Belo Horizonte, MG, Brazil.
European journal of pharmacology
- Publish Date: Jun 2007
- ISSN: 0014-2999
- Volume: 564
- Issue: 1-3
- Pages: 112-5
- Medium: Print
- Language: English
- Citation (JAMA): Reis Glaucia, Pacheco Daniela, Francischi Janetti, et al. Involvement of Gaba A Receptor-associated Chloride Channels in the Peripheral Antinociceptive Effect Induced by Gaba A Receptor Agonist Muscimol.. Eur. J. Pharmacol. Jun 2007;564:112-5
Abstract
The effect of chloride and potassium channel blockers on the antinociception induced by GABA(A) receptor agonist muscimol was investigated using the paw pressure test. Muscimol (1, 2, 4, 8 ng/paw) elicited a peripheral antinociceptive effect that was antagonized by bicuculline (10, 20, 40, 80 ng/paw), suggesting a specific effect. The muscimol effect was reverted by the chloride channel coupled GABA(A) receptor blocker, picrotoxin (0.4, 0.6, 0.8, 2 microg/paw). Potassium channel blockers did not modify the peripheral antinociception induced by muscimol. This study provides evidence that the peripheral antinociceptive effect of muscimol results from the activation of GABA(A) receptor-associated chloride channels.
Mesh Headings (Keywords): Analysis of Variance, Animals, Bicuculline, Chloride Channels, Dinoprostone, Dose-Response Relationship, Drug, GABA Agonists, GABA Antagonists, Injections, Subcutaneous, Male, Muscimol, Pain, Pain Measurement, Picrotoxin, Potassium Channel Blockers, Potassium Channels, Pressure, Rats, Rats, Wistar, Receptors, GABA-A
Check for Full Text / PubMed Unique Identifier (PMID): 17445797
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