New Modes of Exchanger Regulation: Physiological Implications.
From: Department of Pharmacology & Physiology, UMDNJ-Graduate School of Biomedical Sciences, 185 South Orange Avenue, P.O. Box 1709, Newark, NJ 07103, USA. reeves@umdnj.edu
Annals of the New York Academy of Sciences
- Publish Date: Mar 2007
- ISSN: 0077-8923
- Volume: 1099
- Issue:
- Pages: 64-77
- Medium: Print
- Language: English
- Citation (JAMA): Reeves John P, Condrescu Madalina, Urbanczyk Jason, et al. New Modes of Exchanger Regulation: Physiological Implications.. Ann. N. Y. Acad. Sci. Mar 2007;1099:64-77
Abstract
Exchange activity is regulated principally by cytosolic Na+, Ca2+, and PIP2. However, the properties of these modes of regulation that have emerged from excised patch studies appear to be poorly suited to regulating exchange activity on a beat-to-beat basis. Here we summarize recent findings from our lab indicating that (a) allosteric activation by Ca2+ exhibits hysteresis, (b) elevated concentrations of cytosolic Na+ induce a mode of activity that no longer requires regulatory Ca2+ activation, and (c) the requirement for PIP2 is reduced or eliminated after allosteric Ca2+ activation. Our results suggest that exchange activity in cardiac myocytes may be regulated by the time-integral of Ca2+ transients occurring over multiple beats.
Mesh Headings (Keywords): Allosteric Regulation, Animals, Calcium, Cytosol, Sodium, Sodium-Calcium Exchanger
Check for Full Text / PubMed Unique Identifier (PMID): 17446446
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