Functional Significance of Na+/Ca2+ Exchangers Co-localization with Ryanodine Receptors.
From: Computational Biology Group, University of Oxford Computing Laboratory, Wolfson Building, Parks Road, Oxford OX1 3QD, Oxford, UK.
Annals of the New York Academy of Sciences
- Publish Date: Mar 2007
- ISSN: 0077-8923
- Volume: 1099
- Issue:
- Pages: 215-20
- Medium: Print
- Language: English
- Citation (JAMA): Sher Anna A, Hinch Robert, Noble Penelope J, et al. Functional Significance of Na+/Ca2+ Exchangers Co-localization with Ryanodine Receptors.. Ann. N. Y. Acad. Sci. Mar 2007;1099:215-20
Abstract
Co-localization of Na+/Ca2+ exchangers (NCX) with ryanodine receptors (RyRs) is debated. We incorporate local NCX current in a biophysically detailed model of L-type Ca2+ channels (LCCs) and RyRs and study the effect of NCX on the regulation of Ca2+-induced Ca2+ release and the shape of the action potential. In canine ventricular cells, under pathological conditions, e.g., impaired LCCs, local NCXs become an enhancer of sarcoplasmic reticulum release. Under such conditions incorporation of local NCXs is critical to accurately capture mechanisms of excitation-contraction coupling.
Mesh Headings (Keywords): Animals, Models, Theoretical, Ryanodine Receptor Calcium Release Channel, Sodium-Calcium Exchanger
Check for Full Text / PubMed Unique Identifier (PMID): 17446461
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.