Glycan-based Interactions Involving Vertebrate Sialic-acid-recognizing Proteins.
From: Department of Medicine, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, California 92093-0687, USA. a1varki@ucsd.edu
Nature
- Publish Date: Apr 2007
- ISSN: 1476-4687
- Volume: 446
- Issue: 7139
- Pages: 1023-9
- Medium: Internet
- Language: English
- Citation (JAMA): Varki Ajit, et al. Glycan-based Interactions Involving Vertebrate Sialic-acid-recognizing Proteins.. Nature Apr 2007;446:1023-9
Abstract
All cells in nature are covered by a dense and complex array of carbohydrates. Given their prominence on cell surfaces, it is not surprising that these glycans mediate and/or modulate many cellular interactions. Proteins that bind sialic acid, a sugar that is found on the surface of the cell and on secreted proteins in vertebrates, are involved in a broad range of biological processes, including intercellular adhesion, signalling and microbial attachment. Studying the roles of such proteins in vertebrates has improved our understanding of normal physiology, disease and human evolution.
Mesh Headings (Keywords): Animals, Evolution, Molecular, Humans, N-Acetylneuraminic Acid, Polysaccharides, Protein Binding, Proteins, Vertebrates
Check for Full Text / PubMed Unique Identifier (PMID): 17460663
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