Heparan Sulphate Proteoglycans Fine-tune Mammalian Physiology.
From: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA. jesko@ucsd.edu
Nature
- Publish Date: Apr 2007
- ISSN: 1476-4687
- Volume: 446
- Issue: 7139
- Pages: 1030-7
- Medium: Internet
- Language: English
- Citation (JAMA): Bishop Joseph R, Schuksz Manuela, Esko Jeffrey D, et al. Heparan Sulphate Proteoglycans Fine-tune Mammalian Physiology.. Nature Apr 2007;446:1030-7
Abstract
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.
Mesh Headings (Keywords): Animals, Cell Physiology, Heparan Sulfate Proteoglycans, Humans, Mammals
Check for Full Text / PubMed Unique Identifier (PMID): 17460664
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.