• Ward Andrea B
• Warga Rachel M
• Prince Victoria E

Developmental dynamics : an official publication of the American Association of Anatomists

• Publish Date: Jun 2007
• ISSN: 1058-8388
• Volume: 236
• Issue: 6
• Pages: 1558-69
• Medium: Print
• Language: English
• Citation (JAMA): Ward Andrea B, Warga Rachel M, Prince Victoria E, et al. Origin of the Zebrafish Endocrine and Exocrine Pancreas.. Dev. Dyn. Jun 2007;236:1558-69

Abstract

Here, we report a detailed fate map of the zebrafish pancreas at the early gastrula stage of development (6 hours postfertilization; hpf). We show that, at this stage, both pancreas and liver progenitors are symmetrically localized in two broad domains relative to the dorsal organizer. We demonstrate that the dorsal and ventral pancreatic buds can derive from common progenitor pools at 6 hpf, but often derive from independent populations. Endocrine vs. exocrine pancreas show a similar pattern of progenitors, consistent with descriptions of the dorsal bud being strictly endocrine and the ventral bud primarily exocrine. In general, we find that endocrine/dorsal bud progenitors are located more dorsally than the exocrine pancreas/ventral bud progenitors. Later in gastrulation (10 hpf), pancreas progenitors have migrated to bilateral domains at the equator of the embryo. Our fate map will assist with design and interpretation of future experiments to understand early pancreas development.

This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.

Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.

The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.