Murine Cytomegalovirus Major Immediate-early Enhancer Region Operating As a Genetic Switch in Bidirectional Gene Pair Transcription.
From: Institute for Virology, Johannes Gutenberg-University, Hochhaus am Augustusplatz, 55101 Mainz, Germany.
Journal of virology
- Publish Date: Jul 2007
- ISSN: 0022-538X
- Volume: 81
- Issue: 14
- Pages: 7805-10
- Medium: Print
- Language: English
- Citation (JAMA): Simon Christian O, Kühnapfel Birgit, Reddehase Matthias J, et al. Murine Cytomegalovirus Major Immediate-early Enhancer Region Operating As a Genetic Switch in Bidirectional Gene Pair Transcription.. J. Virol. Jul 2007;81:7805-10
Abstract
Enhancers are defined as DNA elements that increase transcription when placed in any orientation relative to a promoter. The major immediate-early (MIE) enhancer region of murine cytomegalovirus is flanked by transcription units ie1/3 and ie2, which are transcribed in opposite directions. We have addressed the fundamental mechanistic question of whether the enhancer synchronizes transcription of the bidirectional gene pair (synchronizer model) or whether it operates as a genetic switch, enhancing transcription of either gene in a stochastic alternation (switch model). Clonal analysis of cytokine-triggered, transcription factor-mediated MIE gene expression from latent viral genomes provided evidence in support of the switch model.
Mesh Headings (Keywords): Animals, Base Sequence, Cytomegalovirus, DNA Primers, Enhancer Elements (Genetics), Genes, Immediate-Early, Mice, Mice, Inbred BALB C, Transcription, Genetic
Check for Full Text / PubMed Unique Identifier (PMID): 17494084
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.