Intranasal Cowpox Virus Infection of the Mouse As a Model for Preclinical Evaluation of Smallpox Vaccines.
From: Unité de Virologie, Centre de Recherches du Service de Santé des Armées (CRSSA) Emile Pardé, F-38702 Grenoble, France.
Vaccine
- Publish Date: Jun 2007
- ISSN: 0264-410X
- Volume: 25
- Issue: 25
- Pages: 4809-17
- Medium: Print
- Language: English
- Citation (JAMA): Ferrier-Rembert Audrey, Drillien Robert, Tournier Jean-Nicolas, et al. Intranasal Cowpox Virus Infection of the Mouse As a Model for Preclinical Evaluation of Smallpox Vaccines.. Vaccine Jun 2007;25:4809-17
Abstract
The intranasal infection of mice with cowpox virus (CPXV) has been evaluated as a model for smallpox infection in man. Administration of a lethal dose of CPXV allowed time for development of T-cell responses but antibodies could not be detected before death occurred. In contrast, infection with a sublethal dose was associated with an early T-cell response followed by neutralising antibodies which correlated with virus clearance. Comparison of two first generation smallpox vaccines revealed no significant differences in terms of immunogenicity, protection and post-challenge virus clearance. These studies show that the CPXV/mouse model is valuable for the initial assessment of smallpox vaccines.
Mesh Headings (Keywords): Administration, Intranasal, Animals, Antibodies, Viral, Antibody Formation, Antibody Specificity, Cowpox, Cowpox virus, Cytokines, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Female, Immunity, Cellular, Lung, Lymphocytes, Mice, Smallpox Vaccine, Spleen, Virus Replication
Check for Full Text / PubMed Unique Identifier (PMID): 17499401
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