The Interferons: 50 Years After Their Discovery, There is Much More to Learn.
From: Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. Pestka@umdnj.edu
The Journal of biological chemistry
- Publish Date: Jul 2007
- ISSN: 0021-9258
- Volume: 282
- Issue: 28
- Pages: 20047-51
- Medium: Print
- Language: English
- Citation (JAMA): Pestka Sidney, et al. The Interferons: 50 Years After Their Discovery, There is Much More to Learn.. J. Biol. Chem. Jul 2007;282:20047-51
Abstract
The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years. This brief review focuses on the discovery and purification of interferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of interferons.
Mesh Headings (Keywords): Animals, Evolution, History, 20th Century, History, 21st Century, Humans, Interferons, Receptor, Interferon alpha-beta
Check for Full Text / PubMed Unique Identifier (PMID): 17502369
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