Early-phase Insulin Secretion is Disturbed in Obese Subjects with Glucose Intolerance.
From: Department of Clinical Biology and Medicine, Institute of Health Bioscience, University of Tokushima, Graduate School, Tokushima 770-8503, Japan. mizuno@clin.med.tokushima-u.ac.jp
Metabolism: clinical and experimental
- Publish Date: Jun 2007
- ISSN: 0026-0495
- Volume: 56
- Issue: 6
- Pages: 856-62
- Medium: Print
- Language: English
- Citation (JAMA): Mizuno Akira, Arai Hidekazu, Fukaya Makiko, et al. Early-phase Insulin Secretion is Disturbed in Obese Subjects with Glucose Intolerance.. Metab. Clin. Exp. Jun 2007;56:856-62
Abstract
The loss of early-phase insulin secretion is a characteristic feature of type 2 diabetes mellitus. The aim of this study is to examine when impairment of early-phase insulin secretion occurs and whether it can be related to increase in insulin resistance caused by obesity. We developed an analytical method to qualify the early-phase insulin secretion; that is, we measured C-peptide immunoreactivity (CPR) response to a selective increase in blood glucose level in portal vein during oral glucose load under a euglycemic hyperinsulinemic clamp (clamp-OGL). Glucose infusion rate, hepatic glucose uptake, and CPR response during clamp-OGL were measured in 30 subjects with diabetes who were divided into 3 groups based on body mass index, 13 obese subjects with normal glucose tolerance (O-NGT), 10 obese subjects with impaired glucose tolerance (O-IGT), and 15 healthy subjects. Significant increase in CPR levels at 10 minutes in clamp-OGL compared with those at steady state was observed in healthy subjects and in O-NGT; however, those were small or absent in diabetic patients and in O-IGT. The incremental ratio of CPR was not correlated to the makers of insulin resistance. The early-phase insulin secretion is well maintained in O-NGT; however, early-phase insulin secretion has already been disturbed in obese subjects with glucose intolerance.
Mesh Headings (Keywords): Adult, Aged, Blood Glucose, C-Peptide, Female, Glucose Intolerance, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Obesity
Check for Full Text / PubMed Unique Identifier (PMID): 17512320
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