Immunological Synapses: Breaking Up May Be Good to Do.
From: The Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0511, USA. matthew.krummel@ucsf.edu
Cell
- Publish Date: May 2007
- ISSN: 0092-8674
- Volume: 129
- Issue: 4
- Pages: 653-5
- Medium: Print
- Language: English
- Citation (JAMA): Krummel Matthew F, et al. Immunological Synapses: Breaking Up May Be Good to Do.. Cell May 2007;129:653-5
Abstract
Activated T cells form stable immunological synapses with antigen-presenting cells whereas naïve T cells initially engage in more transient interactions. Sims et al. (2007) demonstrate that these transient interactions are due to the kinase PKCtheta, which serves to destabilize the synapse thereby permitting T cells to migrate elsewhere. They also show that re-establishment of a synapse involves the actin regulator WASp.
Mesh Headings (Keywords): Animals, Antigen Presentation, Cell Communication, Cell Movement, Humans, Isoenzymes, Lymphocyte Activation, Protein Kinase C, Signal Transduction, T-Lymphocytes, Wiskott-Aldrich Syndrome Protein Family
Check for Full Text / PubMed Unique Identifier (PMID): 17512399
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