Proteasomes: Machines for All Reasons.
From: Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. george.demartino@utsouthwestern.edu
Cell
- Publish Date: May 2007
- ISSN: 0092-8674
- Volume: 129
- Issue: 4
- Pages: 659-62
- Medium: Print
- Language: English
- Citation (JAMA): Demartino George N, Gillette Thomas G, et al. Proteasomes: Machines for All Reasons.. Cell May 2007;129:659-62
Abstract
Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.
Mesh Headings (Keywords): Animals, Homeostasis, Humans, Macromolecular Substances, Proteasome Endopeptidase Complex, Protein Binding, Proteins, Ubiquitin, Ubiquitin-Protein Ligase Complexes
Check for Full Text / PubMed Unique Identifier (PMID): 17512401
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