Selective Downregulation of the High Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes: Differential Regulation from Nondiabetic Subjects.
From: Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. basu.rita@mayo.edu
Diabetes
- Publish Date: Aug 2007
- ISSN: 1939-327X
- Volume: 56
- Issue: 8
- Pages: 2174-7
- Medium: Internet
- Language: English
- Citation (JAMA): Basu Rita, Pajvani Utpal B, Rizza Robert A, et al. Selective Downregulation of the High Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes: Differential Regulation from Nondiabetic Subjects.. Diabetes Aug 2007;56:2174-7
Abstract
OBJECTIVE: Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of insulin-sensitive individuals. We wanted to test whether insulin per se is a contributing factor toward lower plasma adiponectin concentrations and, if so, whether the splanchnic bed contributes to this phenomenon. RESEARCH DESIGN AND METHODS: We sampled femoral artery and hepatic venous samples and measured the high-molecular weight (HMW) and low-molecular weight (LMW) fractions of adiponectin in 11 type 2 diabetic and 7 nondiabetic subjects matched for age, sex, and BMI during basal conditions and during a hyperglycemic (approximately 9.5 mmol/l) hyperinsulinemic (approximately 700 pmol/l) clamp. RESULTS: Under these conditions, total arterial adiponectin, HMW, and the ratio of HMW to total adiponectin all were lower (P < 0.01) in the diabetic versus nondiabetic subjects, whereas the LMW form did not significantly differ. Under hyperinsulinemic conditions, total adiponectin levels dropped, primarily due to a reduction of the HMW form, whereas LMW forms were not significantly affected. CONCLUSIONS: HMW adiponectin and the ratio of HMW to total adiponectin are lower in individuals with diabetes than in nondiabetic subjects. We conclude that HMW adiponectin is downregulated in hyperinsulinemia and type 2 diabetes.
Mesh Headings (Keywords): Adiponectin, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Down-Regulation, Femoral Artery, Humans, Hyperinsulinism, Insulin, Molecular Weight, Splanchnic Circulation
Check for Full Text / PubMed Unique Identifier (PMID): 17513700
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.