Distinct Subsets of Foxp3+ Regulatory T Cells Participate in the Control of Immune Responses.
From: Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Jun 2007
- ISSN: 0022-1767
- Volume: 178
- Issue: 11
- Pages: 6901-11
- Medium: Print
- Language: English
- Citation (JAMA): Stephens Geoffrey L, Andersson John, Shevach Ethan M, et al. Distinct Subsets of Foxp3+ Regulatory T Cells Participate in the Control of Immune Responses.. J. Immunol. Jun 2007;178:6901-11
Abstract
Expression of the transcription factor FoxP3 is the hallmark of regulatory T cells that play a crucial role in dampening immune responses. A comparison of the development and phenotype of FoxP3(+) T cells in relation to the expression of conventional MHC molecules facilitated the identification of several distinct lineages of naive and effector/memory populations of Foxp3(+) T cells. One subpopulation of effector/memory Foxp3(+) T cells develops in the thymic medulla, whereas the second is thymic independent. Both lineages display a distinct activated phenotype, undergo extensive steady-state proliferation, home to sites of acute inflammation, and are unique in their capacity to mediate Ag-nonspecific suppression of T cell activation directly ex vivo. Effector FoxP3(+) T cells may act as a sentinel of tolerance, providing a first line of defense against potentially harmful responses by rapidly suppressing immunity to peripheral self-Ags.
Mesh Headings (Keywords): Animals, Cell Differentiation, Cell Proliferation, Forkhead Transcription Factors, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Immunophenotyping, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Thymus Gland
Check for Full Text / PubMed Unique Identifier (PMID): 17513739
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