High Fviii Level is Associated with Idiopathic Portal Vein Thrombosis in South India.
From: Department of Gastroenterology, Institute of Population Health and Clinical Research, St. John’s Medical College Hospital, Bangalore, India. koshyabe@yahoo.com
The American journal of medicine
- Publish Date: Jun 2007
- ISSN: 1555-7162
- Volume: 120
- Issue: 6
- Pages: 552.e9-11
- Medium: Internet
- Language: English
- Citation (JAMA): Koshy Abraham, Jeyakumari Mary, et al. High Fviii Level is Associated with Idiopathic Portal Vein Thrombosis in South India.. Am. J. Med. Jun 2007;120:552.e9-11
Abstract
BACKGROUND: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism. METHODS: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease. RESULTS: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P <.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P <.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P <.05). CONCLUSIONS: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.
Mesh Headings (Keywords): Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Factor VIII, Female, Humans, India, Male, Middle Aged, Portal Vein, Risk Factors, Thrombosis
Check for Full Text / PubMed Unique Identifier (PMID): 17524760
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