• D’Amico Anthony V
• Chen Ming-Hui
• Catalona William J
• Sun Leon
• Roehl Kimberly A
• Moul Judd W

Cancer

• Publish Date: Jul 2007
• ISSN: 0008-543X
• Volume: 110
• Issue: 1
• Pages: 56-61
• Medium: Print
• Language: English
• Citation (JAMA): D'Amico Anthony V, Chen Ming-Hui, Catalona William J, et al. Prostate Cancer-specific Mortality After Radical Prostatectomy or External Beam Radiation Therapy in Men with 1 or More High-risk Factors.. Cancer Jul 2007;110:56-61

Abstract

BACKGROUND: Estimates of prostate cancer-specific mortality (PCSM) were determined after radical prostatectomy (RP) or radiation therapy (RT) in men with >or=1 high-risk factors. METHODS: The study cohort comprised 948 men who underwent RP (N = 660) or RT (N = 288) for localized prostate cancer between 1988 and 2004 and had at least 1 of the following high-risk factors: a prostate-specific antigen (PSA) velocity >2 ng/mL/year during the year before diagnosis, a biopsy Gleason score of >or=7, a PSA level of >or=10 ng/mL, or clinical category T2b or high disease. Grays regression was used to evaluate whether the number and type of high-risk factors were associated with time to PCSM. RESULTS: Multiple determinants of high risk were found to be significantly associated with a shorter time to PCSM after RP (P < .001) or RT (P 2 ng/mL/year was associated with an increased risk of PCSM after RP (hazards ratio [HR] of 7.3; 95% confidence interval [95% CI], 1.0-59 [P = .05]) or RT (HR of 12.1; 95% CI, 1.4-105 [P = .02]) when compared with men with any other single high-risk factor. CONCLUSIONS: Men with a PSA velocity >2 ng/mL/year had a significantly higher risk of PCSM compared with men who had any other single high-risk factor. These men should be considered for randomized trials evaluating the impact on PCSM from adding systemic agents to standards of care for men with high-risk PC.

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The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.