Alcohol and Folate Consumption and Risk of Benign Proliferative Epithelial Disorders of the Breast.
From: Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, CA, USA.
International journal of cancer. Journal international du cancer
- Publish Date: Sep 2007
- ISSN: 0020-7136
- Volume: 121
- Issue: 6
- Pages: 1346-51
- Medium: Print
- Language: English
- Citation (JAMA): Cui Yan, Page David L, Chlebowski Rowan T, et al. Alcohol and Folate Consumption and Risk of Benign Proliferative Epithelial Disorders of the Breast.. Int. J. Cancer Sep 2007;121:1346-51
Abstract
Alcohol consumption has been associated with increased breast cancer risk and the increase in risk may be attenuated by adequate folate intake. However, their associations with the risk of benign proliferative epithelial disorders (BPEDs) of the breast, possible precursors of breast cancer, are not well understood. To investigate these associations, we conducted a cohort study among 68,132 postmenopausal women participating in the Women’s Health Initiative randomized clinical trials. Women were prospectively followed and those reporting a breast procedure (open surgical biopsy or core needle biopsy) had histological sections obtained for central pathology review. A total of 1,792 women with BPED of the breast were identified over an average of 7.8 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence limits (CLs) for the associations of interest. Compared to nondrinkers, total current alcohol intake of 30 g/day or more was not associated with BPED risk (HR = 0.98, 95% CL = 0.70, 1.38). The risk of BPED was not associated with folate intake from diet (highest vs. lowest quartile: HR = 1.10, 95% CL = 0.96, 1.26), from supplements (yes vs. no: HR = 1.05, 95% CL = 0.96, 1.16) or from all sources combined (highest vs. lowest quartile: HR = 1.11, 95% CL = 0.96, 1.27). Furthermore, there was no effect modification between alcohol and folate in relation to the risk of BPED. In conclusion, we observed that alcohol consumption and folate intake were not associated with altered risk of BPED, and that there was no effect modification between them in relation to the risk of BPED.
Mesh Headings (Keywords): Alcohol Drinking, Breast Diseases, Cohort Studies, Dietary Supplements, Female, Folic Acid, Humans, Postmenopause, Precancerous Conditions, Proportional Hazards Models, Risk Factors, Vitamin B Complex
Check for Full Text / PubMed Unique Identifier (PMID): 17534897
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