Unchecked Thrombin is Bad News for Troubled Arteries.
From: Cardiovascular Research Institute, UCSF, San Francisco, California 94158-2517, USA. eric.camerer@ucsf.edu
The Journal of clinical investigation
- Publish Date: Jun 2007
- ISSN: 0021-9738
- Volume: 117
- Issue: 6
- Pages: 1486-9
- Medium: Print
- Language: English
- Citation (JAMA): Camerer Eric, et al. Unchecked Thrombin is Bad News for Troubled Arteries.. J. Clin. Invest. Jun 2007;117:1486-9
Abstract
Thrombin is clearly a key trigger of thrombosis, the proximal cause of most morbidity and mortality in atherosclerotic cardiovascular disease. Might thrombin also contribute to longer-term, structural changes in the arterial wall that promote narrowing and clotting? A study in this issue of the JCI argues that it can. Aihara et al. report that haploinsufficiency of heparin cofactor II, a glycosaminoglycan-dependent thrombin inhibitor, exacerbates injury- or hyperlipidemia-induced arterial lesion formation in mice, possibly by excessive thrombin signaling through protease-activated receptors (see the related article beginning on page 1514).
Mesh Headings (Keywords): Animals, Arteries, Disease Models, Animal, Heparin Cofactor II, Heterozygote, Humans, Mice, Mice, Knockout, Models, Cardiovascular, Thrombin, Thrombosis
Check for Full Text / PubMed Unique Identifier (PMID): 17549253
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.