Histaminergic Ligands Improve Vestibular Compensation in the Cat: Behavioural, Neurochemical and Molecular Evidence.
From: UMR 6149 Neurobiologie Intégrative et Adaptative, Université de Provence/CNRS, Pôle 3C Comportement, Cerveau, Cognition - Case B - Centre de St Charles, 3 Place Victor Hugo-13331 Marseille Cedex 03-France. tighilet@up.univ-mrs.fr
European journal of pharmacology
- Publish Date: Jul 2007
- ISSN: 0014-2999
- Volume: 568
- Issue: 1-3
- Pages: 149-63
- Medium: Print
- Language: English
- Citation (JAMA): Tighilet Brahim, Mourre Christiane, Trottier Suzanne, et al. Histaminergic Ligands Improve Vestibular Compensation in the Cat: Behavioural, Neurochemical and Molecular Evidence.. Eur. J. Pharmacol. Jul 2007;568:149-63
Abstract
This study analysed the effects of betahistine and thioperamide, two histamine H(3) receptor antagonists, on the recovery process after unilateral vestibular neurectomy (UVN) in the cat. In UVN animals untreated or treated with betahistine or thioperamide, recovery was evaluated by recording the horizontal spontaneous nystagmus and the postural and locomotor performances. The neurochemical effects of these drugs were determined by examining their impact on the histaminergic system. We quantified the mRNA coding for histidine decarboxylase (enzyme synthesizing histamine) by in situ hybridisation in the tuberomammillary nuclei, while binding density to histamine H(3) receptors was assessed using a histamine H(3) receptor agonist ([(3)H]N-alpha-methylhistamine) and autoradiography methods in the tuberomammillary and the vestibular nuclei. Relative to the UVN-untreated group, cats treated with betahistine or thioperamide showed strongly accelerated behavioural recovery. UVN-induced 1) an up-regulation of histidine decarboxylase mRNA in the tuberomammillary nuclei, strongly accentuated under betahistine and thioperamide, 2) a reduction of the binding to histamine H(3) receptors in the vestibular and tuberomammillary nuclei, also strongly enhanced in both groups of treated cats. This study demonstrates that betahistine and thioperamide strongly improve the recovery of vestibular functions in UVN cats by interacting with the histaminergic system.
Mesh Headings (Keywords): Animals, Behavior, Animal, Betahistine, Cats, Histamine Agonists, Histamine Antagonists, Histidine Decarboxylase, Ligands, Methylhistamines, Musculoskeletal Equilibrium, Nystagmus, Pathologic, Piperidines, RNA, Messenger, Receptors, Histamine H3, Vestibular Nerve, Vestibular Nuclei
Check for Full Text / PubMed Unique Identifier (PMID): 17573072
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.