Pre-medication with Intravenous Clonidine Suppresses Fentanyl-induced Cough.
From: Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
Acta anaesthesiologica Scandinavica
- Publish Date: Aug 2007
- ISSN: 0001-5172
- Volume: 51
- Issue: 7
- Pages: 862-5
- Medium: Print
- Language: English
- Citation (JAMA): Horng H-C, Wong C-S, Hsiao K-N, et al. Pre-medication with Intravenous Clonidine Suppresses Fentanyl-induced Cough.. Aug 2007;51:862-5
Abstract
BACKGROUND: A reflex cough is often observed after an intravenous bolus of fentanyl. This study was conducted to determine whether pre-treatment with intravenous clonidine could effectively attenuate fentanyl-induced cough. METHODS: Three hundred ASA I-II patients, aged between 18 and 80 years, undergoing various elective surgeries, were enrolled in this study. All patients were randomly assigned to one of two groups treated with intravenous clonidine 2 microg/kg (clonidine group) or the same volume of normal saline (control group). Intravenous fentanyl (2 microg/kg in 2 s) was injected 2 min after the clonidine or normal saline injection. Changes in the hemodynamics, auditory evoked potentials (AEPs) and Observer Assessment of Alertness/Sedation (OAA/S) rating scale were recorded before and 2 min after the clonidine or normal saline injection and 1 min after the fentanyl injection. The number of coughs 1 min after the fentanyl injection was also recorded. RESULTS: Patients in the clonidine group showed a significantly lower incidence of cough than those in the control group (17.3% vs. 38.7%, respectively; P < 0.01). The blood pressure was lower in the clonidine group than in the control group. There were no significant differences in AEP or OAA/S rating scale. CONCLUSIONS: Pre-treatment with intravenous clonidine (2 microg/kg) suppressed the reflex cough induced by fentanyl, with mild hemodynamic changes. Therefore, intravenous clonidine may be a clinically useful method of suppressing fentanyl-induced cough.
Mesh Headings (Keywords): Adolescent, Adrenergic alpha-Agonists, Adult, Aged, Aged, 80 and over, Analgesics, Opioid, Blood Pressure, Clonidine, Cough, Female, Fentanyl, Heart Rate, Humans, Male, Middle Aged, Preanesthetic Medication, Prospective Studies
Check for Full Text / PubMed Unique Identifier (PMID): 17578464
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