Biomarkers for Radiation-induced Small Bowel Epithelial Damage: an Emerging Role for Plasma Citrulline.
From: Department of Radiation Oncology (Maastro), GROW Research Institute, University of Maastricht, Tanslaan 12, 6202 AZ Maastricht, The Netherlands. ludy.lutgens@maastro.nl
World journal of gastroenterology : WJG
- Publish Date: Jun 2007
- ISSN: 1007-9327
- Volume: 13
- Issue: 22
- Pages: 3033-42
- Medium: Print
- Language: English
- Citation (JAMA): Lutgens Ludy, Lambin Philippe, et al. Biomarkers for Radiation-induced Small Bowel Epithelial Damage: an Emerging Role for Plasma Citrulline.. World J. Gastroenterol. Jun 2007;13:3033-42
Abstract
Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specific objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail.
Mesh Headings (Keywords): Animals, Apoptosis, Biological Markers, Citrulline, Enterocytes, Humans, Intestinal Mucosa, Intestine, Small, Radiation Injuries
Check for Full Text / PubMed Unique Identifier (PMID): 17589917
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