• Eberli Franz R
• Roffi Marco

Herz

• Publish Date: Jun 2007
• ISSN: 0340-9937
• Volume: 32
• Issue: 4
• Pages: 301-6
• Medium: Print
• Language:
• Citation (JAMA): Eberli Franz R, Roffi Marco, et al. Treatment After Drug-eluting Stent Placement. Jun 2007;32:301-6

Abstract

The use of drug-eluting stents (DES) in percutaneous coronary interventions (PCI) decreased the rate of restenosis and hence the need for repeat revascularization by 50-71%. DES have changed PCI. DES allow successful revascularization of anatomically challenging lesions, such as long, thin vessels, bifurcation lesions, and chronic total occlusions. A rare, but severe complication of coronary stenting is stent thrombosis, a partial or total thrombotic occlusion of the stent. The use of DES for increasingly more complex lesions, the prothrombotic effect of the antiproliferative substances, and a delayed endothelialization of DES all potentially prolong and increase the risk of stent thrombosis. Dual antiplatelet therapy for 1 year is therefore recommended after DES placement. There is currently no evidence for the efficacy and safety of routine dual antiplatelet therapy beyond 1 year. It is also recommended postponing elective surgery for 1 year and, if surgery cannot be deferred, considering continuation of acetylsalicylic acid during the perioperative period in high-risk patients with DES.

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The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.