Attenuated Herpes Simplex Virus 1 Blocks Arterial Apoptosis and Intimal Hyperplasia Induced by Balloon Angioplasty and Reduced Blood Flow.
From: Section of Vascular Surgery, Department of Surgery, University of Chicago, Chicago, IL 60637, USA. cskelly@surgery.bsd.uchicago.edu
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Jul 2007
- ISSN: 0027-8424
- Volume: 104
- Issue: 30
- Pages: 12474-8
- Medium: Print
- Language: English
- Citation (JAMA): Skelly Christopher L, Chandiwal Amito, Vosicky James E, et al. Attenuated Herpes Simplex Virus 1 Blocks Arterial Apoptosis and Intimal Hyperplasia Induced by Balloon Angioplasty and Reduced Blood Flow.. Proc. Natl. Acad. Sci. U.S.A. Jul 2007;104:12474-8
Abstract
Injury caused by distention of the arterial wall by balloon angioplasty can result in apoptosis and vascular smooth muscle cell proliferation. Here, we report that a brief exposure of the arterial lumen to a genetically engineered, attenuated herpes simplex virus 1 blocks activation of caspase 3-dependent apoptosis and MAPK-dependent cell proliferation induced by carotid artery balloon angioplasty and ligation to reduce blood flow. The procedure enables the restoration of the endothelial cell layer lining the lumen and prevents neointimal hyperplasia and restenosis. These findings have a broad application in prevention of balloon angioplasty-induced restenosis.
Mesh Headings (Keywords): Angioplasty, Balloon, Animals, Apoptosis, Arteries, Caspase 3, Extracellular Signal-Regulated MAP Kinases, Herpesvirus 1, Human, Hyperplasia, Male, Mutation, Proliferating Cell Nuclear Antigen, Rabbits, Regional Blood Flow
Check for Full Text / PubMed Unique Identifier (PMID): 17626787
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