The Cannabinoid Cb1 Receptor Antagonist Am251 Does Not Modify Methamphetamine Reinstatement of Responding.
From: Cajal Neuroscience Institute, Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA.
European journal of pharmacology
- Publish Date: Sep 2007
- ISSN: 0014-2999
- Volume: 571
- Issue: 1
- Pages: 39-43
- Medium: Print
- Language: English
- Citation (JAMA): Boctor Sherin Y, Martinez Joe L, Koek Wouter, et al. The Cannabinoid Cb1 Receptor Antagonist Am251 Does Not Modify Methamphetamine Reinstatement of Responding.. Eur. J. Pharmacol. Sep 2007;571:39-43
Abstract
Cannabinoid CB(1) receptor antagonists can decrease methamphetamine self-administration. This study examined whether the CB(1) receptor antagonist AM251 [N-(piperidin-1-yl)-5-(4-indophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide] modifies reinstatement in rats that previously self-administered methamphetamine. Rats (n=10) self-administered methamphetamine (0.1 mg/kg/infusion) under a fixed ratio 2 schedule. Non-contingent methamphetamine (0.01-1.78 mg/kg, i.v.) yielded responding for saline (reinstatement) that was similar to responding for self-administered methamphetamine. AM251 (0.032-0.32, i.v.) did not affect methamphetamine-induced reinstatement but significantly attenuated Delta(9)-tetrahydrocannabinol (2.0 mg/kg, i.p.)-induced hypothermia. These data fail to support a role for endogenous cannabinoids or cannabinoid CB(1) receptors in reinstatement and, therefore, relapse to stimulant abuse.
Mesh Headings (Keywords): Animals, Body Temperature, Central Nervous System Stimulants, Dose-Response Relationship, Drug, Infusions, Intravenous, Injections, Intraperitoneal, Male, Methamphetamine, Piperidines, Pyrazoles, Rats, Rats, Wistar, Receptor, Cannabinoid, CB1, Reinforcement Schedule, Self Administration, Tetrahydrocannabinol, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17628534
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