Prion Protein Facilitates Hormone-induced Differentiation of Mammary Gland Epithelial Cells.
From: Upper Austrian Research GmbH, Center for Biomedical Nanotechnology, Scharitzerstrasse 6-8, 4020 Linz, Austria.
Biochemical and biophysical research communications
- Publish Date: Sep 2007
- ISSN: 0006-291X
- Volume: 360
- Issue: 4
- Pages: 746-51
- Medium: Print
- Language: English
- Citation (JAMA): Mörwald Helene, Wurm Susanne, Crailsheim Karl, et al. Prion Protein Facilitates Hormone-induced Differentiation of Mammary Gland Epithelial Cells.. Biochem. Biophys. Res. Commun. Sep 2007;360:746-51
Abstract
Expression of prion protein has been reported for a variety of cell types including neuronal cells, haematopoietic stem cells, lymphocytes, fibroblasts, and epithelial cells. However, the characterization of the physiological roles exhibited by this protein is still in progress and multiple biological functions have been described to date. In this study we have characterized the contribution of prion protein during hormone-induced differentiation of mouse mammary gland epithelial cells. We present evidence that prion expression enhances the differentiation-capabilities of these cells indicating novel physiological roles during mammary gland development. In addition we were able to demonstrate the presence of prion molecules resistant to mild proteinase digestion in differentiated mammary gland epithelial cells. This represents the first report of proteinase-resistant prion proteins in a physiological, non-pathogenic context.
Mesh Headings (Keywords): Animals, Caseins, Cell Differentiation, DNA, Complementary, Epithelial Cells, Mammary Glands, Animal, Mice, PrPC Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17631862
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