Application of Dna Microarray Technology to Gerontological Studies.
From: Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2007
- ISSN: 1064-3745
- Volume: 371
- Issue:
- Pages: 249-65
- Medium: Print
- Language: English
- Citation (JAMA): Anisimov Sergey V, et al. Application of Dna Microarray Technology to Gerontological Studies.. Methods Mol. Biol. 2007;371:249-65
Abstract
The emergence of microarray technology as a novel tool in molecular biology has led to significant progress in many biomedical disciplines, including gerontology. Both cDNA and oligonucleotide-based DNA microarrays are now widely used to identify the basic physiological mechanisms of aging and to uncover the molecular mechanisms underlying the biological effects of anti-aging drugs. Two different protocols covering both cDNA and oligonucleotide microarray platforms, with radioactive and nonradioactive (fluorescent) labeling, are detailed in the manuscript. These in-depth protocols provide a background for the technical aspects of everyday work with DNA microarrays.
Mesh Headings (Keywords): Aging, Animals, Humans, Oligonucleotide Array Sequence Analysis
Check for Full Text / PubMed Unique Identifier (PMID): 17634587
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