Technical Note: Calculation of Standard Errors of Estimates of Genetic Parameters with the Multiple-trait Derivative-free Restricted Maximal Likelihood Programs.
From: Department of Statistics, University of Nebraska, Lincoln 68583-0963, USA.
Journal of animal science
- Publish Date: Oct 2007
- ISSN: 1525-3163
- Volume: 85
- Issue: 10
- Pages: 2375-81
- Medium: Internet
- Language: English
- Citation (JAMA): Kachman S D, Van Vleck L D, et al. Technical Note: Calculation of Standard Errors of Estimates of Genetic Parameters with the Multiple-trait Derivative-free Restricted Maximal Likelihood Programs.. J. Anim. Sci. Oct 2007;85:2375-81
Abstract
The multiple-trait derivative-free REML set of programs was written to handle partially missing data for multiple-trait analyses as well as single-trait models. Standard errors of genetic parameters were reported for univariate models and for multiple-trait analyses only when all traits were measured on animals with records. In addition to estimating (co)variance components for multiple-trait models with partially missing data, this paper shows how the multiple-trait derivative-free REML set of programs can also estimate SE by augmenting the data file when not all animals have all traits measured. Although the standard practice has been to eliminate records with partially missing data, that practice uses only a subset of the available data. In some situations, the elimination of partial records can result in elimination of all the records, such as one trait measured in one environment and a second trait measured in a different environment. An alternative approach requiring minor modifications of the original data and model was developed that provides estimates of the SE using an augmented data set that gives the same residual log likelihood as the original data for multiple-trait analyses when not all traits are measured. Because the same residual vector is used for the original data and the augmented data, the resulting REML estimators along with their sampling properties are identical for the original and augmented data, so that SE for estimates of genetic parameters can be calculated.
Mesh Headings (Keywords): Animals, Breeding, Female, Genetic Markers, Genotype, Likelihood Functions, Male, Models, Biological, Multivariate Analysis, Quantitative Trait Loci, Software
Check for Full Text / PubMed Unique Identifier (PMID): 17644790
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