Cellular Senescence in Cancer and Aging.
From: Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Cell
- Publish Date: Jul 2007
- ISSN: 0092-8674
- Volume: 130
- Issue: 2
- Pages: 223-33
- Medium: Print
- Language: English
- Citation (JAMA): Collado Manuel, Blasco Maria A, Serrano Manuel, et al. Cellular Senescence in Cancer and Aging.. Cell Jul 2007;130:223-33
Abstract
Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.
Mesh Headings (Keywords): Aging, Animals, Cell Aging, Cyclin-Dependent Kinase Inhibitor p16, DNA Damage, Humans, Neoplasms, Telomere
Check for Full Text / PubMed Unique Identifier (PMID): 17662938
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