Dna Repair Capacity of Zebrafish.
From: Marine Biological Laboratory, Woods Hole, MA 02543, USA. rsussman@mbl.edu
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Aug 2007
- ISSN: 0027-8424
- Volume: 104
- Issue: 33
- Pages: 13379-83
- Medium: Print
- Language: English
- Citation (JAMA): Sussman Raquel, et al. Dna Repair Capacity of Zebrafish.. Proc. Natl. Acad. Sci. U.S.A. Aug 2007;104:13379-83
Abstract
Damage to the genome is unavoidable in living creatures, because of sunlight exposure as well as environmental chemicals present in food and drinking water. There is a need to monitor and purify the drinking water; therefore, several methods of detection have been developed. A very promising model system for this purpose is the zebrafish (Danio rerio), which is endowed with special qualities for detecting external as well as internal abnormalities. Grossman and Wei’s assay [Grossman L, Wei Q (1995) Clin Chem 12:1854-1863], which measures the expression level of a nonreplicating recombinant plasmid DNA containing a UV-damaged luciferase reporter gene, shows that zebrafish can repair chromosomal lesions to a much greater extent than the human population. This vertebrate model is still very promising after possible down-regulation of the DNA repair enzymes.
Mesh Headings (Keywords): Animals, DNA Repair, Plasmids, Zebrafish
Check for Full Text / PubMed Unique Identifier (PMID): 17686971
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