Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery.
From: Department of Internal Medicine, Metabolic Unit, Università Cattolica S. Cuore, Rome, Italy.
Obesity (Silver Spring, Md.)
- Publish Date: Aug 2007
- ISSN: 1930-7381
- Volume: 15
- Issue: 8
- Pages: 2012-8
- Medium: Print
- Language: English
- Citation (JAMA): Valera Mora Maria E, Manco Melania, Capristo Esmeralda, et al. Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery.. Aug 2007;15:2012-8
Abstract
OBJECTIVE: The objective was to evaluate ghrelin and growth hormone (GH) interactions and responses to a growth hormone-releasing hormone (GHRH)/arginine test in severe obesity before and after surgically-induced weight loss. RESEARCH METHODS AND PROCEDURES: Our study population included 11 severely obese women 39 +/- 12 years of age, with a mean BMI of 48.6 +/- 2.4 kg/m2, re-studied in a phase of stabilized body weight, with a BMI of 33.4 +/- 1.2 kg/m2, 18 months after having successfully undergone biliopancreatic diversion (BPD). A GHRH/arginine test was performed before and 18 months after BPD to evaluate ghrelin and GH interactions. Active ghrelin, measured by radioimmunoassay (RIA), and GH, measured by chemiluminescence assay, were assayed before and after the GHRH/arginine test. RESULTS: Fasting serum GH levels and GH area under the curve (AUC) significantly increased from 0.2 +/- 0.05 ng/mL to 1 +/- 0.3 ng/mL (p < 0.05) and from 514.76 +/- 98.7 ng/mL for 120 minutes to 1957.3 +/- 665.1 ng/mL for 120 minutes after bariatric surgery (p < 0.05), respectively. Although no significant change in fasting ghrelin levels was observed (573 +/- 77.9 before BPD vs. 574.1 +/- 32.7 after BPD), ghrelin AUC significantly increased from -3253.9 +/- 2180.9 pg/mL for 120 minutes to 1142.3 +/- 916.4 pg/mL for 120 minutes after BPD (p < 0.05). Fasting serum insulin-like growth factor (IGF)-1 concentration did not change significantly (133.6 +/- 9.9 ng/mL before vs. 153.3 +/- 25.2 ng/mL after BPD). DISCUSSION: Our study demonstrates that the mechanisms involved in ghrelin and GH secretion after the secretagogue stimulus (GHRH/arginine) are consistent with patterns observed in other populations.
Mesh Headings (Keywords): Adult, Arginine, Biliopancreatic Diversion, Blood Glucose, Female, Ghrelin, Growth Hormone, Growth Hormone-Releasing Hormone, Humans, Insulin, Insulin-Like Growth Factor I, Leptin, Middle Aged, Obesity, Morbid, Peptide Hormones, Weight Loss
Check for Full Text / PubMed Unique Identifier (PMID): 17712119
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.