Veterinary Autoimmunity: Autoimmune Diseases in Domestic Animals.
From: Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, One Shields Ave., Davis, CA 95616, USA. ljgershwin@ucdavis.edu
Annals of the New York Academy of Sciences
- Publish Date: Aug 2007
- ISSN: 0077-8923
- Volume: 1109
- Issue:
- Pages: 109-16
- Medium: Print
- Language: English
- Citation (JAMA): Gershwin Laurel J, et al. Veterinary Autoimmunity: Autoimmune Diseases in Domestic Animals.. Ann. N. Y. Acad. Sci. Aug 2007;1109:109-16
Abstract
The first spontaneous animal model of autoimmunity was the New Zealand black mouse, discovered in 1959. Interestingly, although several models of induced autoimmunity were demonstrated in a variety of rodents, the recognition of autoimmune disease in dogs came somewhat later. Dog breeding and selection of traits within certain dog breeds have become an important enterprise with intensive husbandry and selection criteria being applied to each breed standard. This has resulted in breeding for specific phenotypic characteristics. This selection has inadvertently led to the propagation of a number of autoimmune diseases in dogs. For example, systemic lupus erythematosus (SLE), autoimmune hemolytic anemia and thrombocytopenia, autoimmune myasthenia gravis, and diabetes mellitus are now fairly common. In the final analysis, the appearance of autoimmunity in dogs reflects their breeding selection and illustrates the importance of genetics in the development of autoimmune disease.
Mesh Headings (Keywords): Animals, Arthritis, Rheumatoid, Autoimmunity, Dog Diseases, Dogs, Female, Humans, Lupus Erythematosus, Systemic, Male, Thrombocytopenia
Check for Full Text / PubMed Unique Identifier (PMID): 17785296
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.